This toolbox talk provides a comprehensive safety briefing for cleaning staff, healthcare workers, facilities managers and any personnel tasked with cleaning blood, vomit, urine and other bodily fluid spillages. It details infection risks from blood‑borne pathogens such as hepatitis B, C and HIV, chemical hazards from disinfectants, slip hazards on wet surfaces and manual handling challenges. Practical DO and DON’T actions are presented with clear step‑by‑step guidance, supported by regulatory references and direct links to official HSE guidance and UK legislation. The guidance highlights the importance of double‑gloving for high‑risk spills, conducting a COSHH risk assessment for large volumes, ensuring proper ventilation and immediate hand hygiene after PPE removal. Use this template to meet the requirements of the Health and Safety at Work Act 1974, COSHH Regulations 2002 and Workplace (Health, Safety and Welfare) Regulations 1992. It is ideal for hospitals, clinics, care homes, schools, prisons and any workplace where exposure to bodily fluids may occur, helping organisations protect staff, patients and visitors. Regular audits of cleaning procedures and spill response drills should be carried out quarterly to ensure ongoing compliance and to identify areas for improvement. All staff must be familiar with the location of spill kits and the correct method for sealing and disposing of contaminated materials.