This office cleaning toolbox talk provides detailed, practical guidance for cleaning staff, facilities managers and office supervisors on safe cleaning and workstation sanitisation in modern workplaces. It explains how to control chemical hazards such as bleach, isopropyl alcohol and quaternary ammonium compounds, manage slip risks from wet floors, and apply safe manual handling techniques for equipment. The talk references key UK regulations, including the Health and Safety at Work Act 1974, COSHH Regulations 2002 and the Workplace (Health, Safety and Welfare) Regulations 1992, and links to authoritative HSE guidance and legislation. By following the DO and DON’T actions, organisations can reduce incident rates, ensure compliance for audits, and protect employee health. The content also highlights the importance of proper ventilation, low‑VOC disinfectants, correct PPE selection, and systematic risk‑assessment documentation, supporting ISO 45001 safety management objectives. It also covers safe storage of cleaning agents, waste segregation, and emergency spill procedures, and provides a supervisor checklist to verify controls before work begins. All staff should review the emergency spill response plan and ensure spill kits are readily accessible. Regular refresher training should be recorded in the training register to demonstrate ongoing competence. Conduct periodic safety audits and update the cleaning protocol to reflect any new hazards or regulatory changes, reinforcing a culture of continuous improvement.